16 – Excitation–Contraction Coupling

@inproceedings{Bers200116E,
  title={16 – Excitation–Contraction Coupling},
  author={Donald M. Bers},
  year={2001}
}
Since the classic experiments of Ringer (1883) demonstrated that the frog heart would not contract in the absence of extracellular Ca, it has been clear that Cao is critical in muscle contraction. This has been confirmed repeatedly and some modern day extensions of this fundamental observation are illustrated in Figs. 55 and 56. Figure 55A shows that when Cao is removed quickly from the medium around a rat ventricular myocyte contractions are immediately abolished (in < 1 sec, Rich et al, 1988… CONTINUE READING

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