15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor.

@article{Napimoga200815dprostaglandinJI,
  title={15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor.},
  author={Marcelo Henrique Napimoga and Guilherme Rocha Lino de Souza and Thiago M Cunha and Luiz F Ferrari and Juliana Trindade Clemente-Napimoga and Carlos Am{\'i}lcar Parada and Waldiceu A Verri and Fernando Q Cunha and S{\'e}rgio Henrique Ferreira},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 1},
  pages={313-21}
}
The 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an endogenous ligand of peroxisome proliferator-activated receptors gamma (PPAR-gamma) and is now recognized as a potent anti-inflammatory mediator. However, information regarding the influence of 15d-PGJ(2) on inflammatory pain is still unknown. In this study, we evaluated the effect of 15d-PGJ(2… CONTINUE READING