15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line.

@article{Chen200315dPGJ2IC,
  title={15d-PGJ2 inhibits cell growth and induces apoptosis of MCG-803 human gastric cancer cell line.},
  author={Yun-xian Chen and Xue-yun Zhong and Yan-fang Qin and Wang Bing and L He},
  journal={World journal of gastroenterology},
  year={2003},
  volume={9 10},
  pages={2149-53}
}
AIM To investigate the influence of peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, 15-deoxy-12, 14-prostaglandin J2 (15dPGJ2) on the proliferation and apoptosis of MCG-803 human gastric cancer cell lines. METHODS Cell proliferation was measured by 3H-TdR assay. Apoptosis was determined by ELISA and TUNEL staining. Protein and mRNA level of bcl-2 family and COXs were measured by Western blotting and Northern blotting respectively. PGE2 production was examined by RIA… CONTINUE READING