15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH

Abstract

15N nuclear spins of imidazole-15N2 were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A 15N NMR signal enhancement of ∼2000-fold at 9.4 T is reported using parahydrogen gas (∼50% para-) and ∼0.1 M imidazole-15N2 in methanol:aqueous buffer (∼1:1). Proton binding to a… (More)

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@inproceedings{Shchepin201615NHO, title={15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH}, author={Roman V. Shchepin and Danila A Barskiy and Aaron M. Coffey and Thomas Theis and Fan Shi and Warren S. Warren and Boyd M Goodson and Eduard Y Chekmenev}, booktitle={ACS sensors}, year={2016} }