1539 Big Renin Stimulation of Blood Pressure, and the Renin-angiotensin System in the Newborn Puppy


Renin activity increases in vitro upon exposure to acid pH 3.3 followed by alkaline pH 7.4, low temperature, the proteases trypsin and pepsin, and urinary kallikrein. The purpose of this study was to determine the effect of big renin (M.W. 56,000, purified from human cord blood), on blood pressure (B.P.), the renin-angiotensin-aldosterone system, and renal… (More)
DOI: 10.1203/00006450-198104001-01562


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