15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.

  title={15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.},
  author={H H Tai and Min Tong and Yunfei Ding},
  journal={Prostaglandins & other lipid mediators},
  volume={83 3},
15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD(+)-linked oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and is the key enzyme responsible for the biological inactivation of these eicosanoids. The enzyme was found to be under-expressed as opposed to cyclooxygenase-2 (COX-2) being over-expressed in lung and other tumors. A549 human lung adenocarcinoma cells were used as a model system to study the role of 15-PGDH in lung tumorigenesis. Up-regulation of COX-2… CONTINUE READING
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