15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.

@article{AlvarezMaqueda200415deoxydelta1J,
  title={15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.},
  author={Mois{\'e}s Alvarez-Maqueda and Rajaa El Bekay and Gonzalo Alba and Javier Monteseir{\'i}n and Pedro Chac{\'o}n and Antonio Trist{\'a}n Vega and Jos{\'e} Mart{\'i}n-Nieto and Francisco J Bedoya and Elisabeth Pintado and Francisco Sobrino},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 21},
  pages={21929-37}
}
15-Deoxy-delta(12,14)-prostaglandin J(2) (15dPGJ(2) has been recently proposed as a potent anti-inflammatory agent. However, the mechanisms by which 15dPGJ(2) mediates its therapeutic effects in vivo are unclear. We demonstrate that 15dPGJ(2) at micromolar (2.5-10 microm) concentrations induces the expression of heme oxygenase-1 (HO-1), an anti-inflammatory enzyme, at both mRNA and protein levels in human lymphocytes. In contrast, troglitazone and ciglitazone, two thiazolidinediones that mimic… CONTINUE READING
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