Corpus ID: 38246346

15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.

@article{Kawahito200015deoxydelta1214PGJ2IS,
  title={15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.},
  author={Y. Kawahito and M. Kondo and Y. Tsubouchi and A. Hashiramoto and D. Bishop-Bailey and K. Inoue and M. Kohno and R. Yamada and T. Hla and H. Sano},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 2},
  pages={
          189-97
        }
}
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and have a dominant regulatory role in adipocyte and monocyte differentiation. PPAR-gamma agonists are also negative regulators of macrophage activation and have modulatory effects on tumorigenesis. In this study we demonstrate that synovial tissue localized expression of PPAR-gamma in patients with rheumatoid arthritis (RA). We detected markedly enhanced expression of PPAR-gamma in… Expand
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