15 PERK and Translational Control by Stress in the Endoplasmic Reticulum

@inproceedings{Ron200015PA,
  title={15 PERK and Translational Control by Stress in the Endoplasmic Reticulum},
  author={David Ron and Heather P Harding},
  year={2000}
}
TRANSLATIONAL CONTROL IN THE UNFOLDED PROTEIN RESPONSE: HISTORICAL BACKGROUND Protein folding is the last step in gene expression. The information required for folding is encoded in the genome and is an intrinsic property of the translated polypeptide. However, in the crowded environment of the cell this process is rarely spontaneous; specific chaperone systems have evolved to assist in folding (Anfinsen 1973). The work they perform is energetically very costly and their function is dependent… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Dysfunction of the unfolded protein response during global brain ischemia and reperfusion.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2002
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED