15-O-Acetyl-3-O-benzoylcharaciol and helioscopinolide A, two diterpenes isolated from Euphorbia helioscopia suppress microglia activation

@article{Wang201615OAcetyl3ObenzoylcharaciolAH,
  title={15-O-Acetyl-3-O-benzoylcharaciol and helioscopinolide A, two diterpenes isolated from Euphorbia helioscopia suppress microglia activation},
  author={Huisheng Wang and Yu Liu and Jingling Zhang and Jing Xu and Chun-ai Cui and Yuanqiang Guo and Da-qing Jin},
  journal={Neuroscience Letters},
  year={2016},
  volume={612},
  pages={149-154}
}
Microglia activation plays an important role in the pathogenesis of various neurodegenerative diseases by producing neurotoxic factors. In the present study, we found that two diterpenes isolated from Euphorbia helioscopia, 15-O-Acetyl-3-O-benzoylcharaciol and helioscopinolide A suppressed NO and PGE2 production by inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. The diterpenes also inhibited… Expand
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