15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.

@article{Shen201515LipoxygenaseA1,
  title={15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.},
  author={Tingting Shen and Jiucheng Shi and Na Li Wang and X Yu and Chen Zhang and Jing Li and Liuping Wei and Cui Cui Ma and Xijuan Zhao and Mingming Lian and Chun Hui Jiang and Daling Zhu},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={309 5},
  pages={L449-62}
}
Pulmonary arterial hypertension (PAH) is a disease characterized by thickening of pulmonary artery walls, elevated pulmonary vascular resistance, pulmonary vascular thrombotic lesions, and right heart failure. Recent studies suggest that 15-lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) play an important role in PAH, acting on arterial walls. Here, we show evidence for the action of the 15-LO/15-HETE signaling in the pulmonary vascular thrombotic lesions in the experimental PAH… CONTINUE READING
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