15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.

@article{Zhao201115Lipoxygenase1I,
  title={15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.},
  author={Jinming Zhao and Valerie B O'Donnell and Silvana Balzar and Claudette M St Croix and John B. Trudeau and Sally E Wenzel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 34},
  pages={14246-51}
}
Epithelial 15-lipoxygenase 1 (15LO1) and activated ERK are increased in asthma despite modest elevations in IL-13. MAPK kinase (MEK)/ERK activation is regulated by interactions of Raf-1 with phosphatidylethanolamine-binding protein 1 (PEBP1). Epithelial 15LO1 generates intracellular 15-hydroxyeicosatetraenoic acid (15HETE) conjugated to phosphatidylethanolamine (PE) (15HETE-PE). We hypothesized that (i) 15LO1 and its product 15HETE-PE serve as signaling molecules interacting with PEBP1 to… CONTINUE READING