15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells

@article{Zuo200915LOX1TS,
  title={15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells},
  author={Xiangsheng Zuo and Jeffrey S. Morris and Russell E. Broaddus and Imad Shureiqi},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={1496-1505}
}
15-Lipoxygenase-1 (15-LOX-1) is transcriptionally silenced in cancer cells, and its transcription reactivation (for example, through histone deacetylase inhibitors (HDACIs)) restores apoptosis to cancer cells. However, the exact mechanism underlying 15-LOX-1 transcription reactivation in cancer cells is still undefined. Therefore, we evaluated the critical mechanisms required for 15-LOX-1 transcription reactivation in colon cancer cells. Specific HDAC1 and HDAC2 inhibition activated 15-LOX-1… CONTINUE READING
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