15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells.

@article{Lehtinen201215HydroxyprostaglandinDA,
  title={15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells.},
  author={Laura Lehtinen and Paula Vainio and Harriet Wikman and Johannes Reemts and Mika Hilvo and Rana M Issa and Sirkku Pollari and Burkhard Brandt and Matej Ore{\vs}i{\vc} and Klaus Pantel and Olli Kallioniemi and Kristiina Iljin},
  journal={The Journal of pathology},
  year={2012},
  volume={226 4},
  pages={674-86}
}
Breast cancer is the most frequent cancer and the leading cause of cancer-related deaths in women worldwide. The prognosis of breast cancer is tightly correlated with the degree of spread beyond the primary tumour. Arachidonic acid (AA) and prostaglandin E(2) (PGE(2)) are known to regulate tumour metastasis enabling epithelial-mesenchymal transition (EMT). However, the detailed role of 15-hydroxyprostaglandin dehydrogenase (HPGD), the key enzyme degrading prostaglandin E(2) , remains unclear in… CONTINUE READING