15-Hydroxy-prostanoate dehydrogenase. Prostaglandins as substrates and inhibitors.

Abstract

Determination of Michaelis constnats and maximum reaction rates for a series of prostaglandin dehydrogenase substrates showed that the enzyme is stereospecific with regard to configuration at C-15. Substituents of the cyclopentane ring did not markedly affect the properties as a substrate, whereas the nature of the carboxyl side chain proved important. A… (More)

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