15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2.

@article{Kim200815DeoxyDelta1214prostaglandinJR,
  title={15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2.},
  author={Ji-Woo Kim and Mei-hua Li and Jung-Hee Jang and Hye-Kyung Na and Na-Young Song and Chan Lee and J Aaron Johnson and Y. -J. Surh},
  journal={Biochemical pharmacology},
  year={2008},
  volume={76 11},
  pages={1577-89}
}
Oxidative stress induced by reactive oxygen intermediates has been implicated in a variety of human diseases including rheumatoid arthritis and neurodegenerative disorders. 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a terminal dehydration product of prostaglandin D(2), is an endogenous ligand of peroxisome proliferator-activated receptor-gamma and exhibits a number of biological activities including the proapoptotic activity. Recent studies have revealed that this cyclopentenone… CONTINUE READING

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