15-Deoxy-Δ(12,14)-prostaglandin J2 exerts pro- and anti-inflammatory effects in mesangial cells in a concentration-dependent manner.

Abstract

Cyclopentenone prostaglandins play a modulatory role in inflammation, in part through their ability to covalently modify key proinflammatory proteins. Using mesangial cells as a cellular model of inflammation we have observed that 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) exerts a biphasic effect on cell activation by cytokines, with nanomolar… (More)

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Cite this paper

@article{Martnez201215Deoxy1214prostaglandinJE, title={15-Deoxy-Δ(12,14)-prostaglandin J2 exerts pro- and anti-inflammatory effects in mesangial cells in a concentration-dependent manner.}, author={Alma Mart{\'i}nez and Francisco Sanchez-Gomez and Beatriz D{\'i}ez-Dacal and Clara L. Oeste and Dolores P{\'e}rez-Sala}, journal={Inflammation & allergy drug targets}, year={2012}, volume={11 1}, pages={58-65} }