14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

@article{Diacon201214dayBA,
  title={14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial},
  author={A. H. Diacon and Rodney Dawson and Florian von Groote-Bidlingmaier and Gregory Symons and Melvin K. Spigelman},
  journal={The Lancet},
  year={2012},
  volume={380},
  pages={986-993}
}
BACKGROUND New drugs, but also shorter, better-tolerated regimens are needed to tackle the high global burden of tuberculosis complicated by drug resistance and retroviral disease. We investigated new multiple-agent combinations over the first 14 days of treatment to assess their suitability for future development. METHODS In this prospective, randomised, early bactericidal activity (EBA) study, treatment-naive, drug-susceptible patients with uncomplicated pulmonary tuberculosis were admitted… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combination: a randomised trial

AH Diacon, R Dawson, F von Groote-Bidlingmaier
  • Lancet
  • 2012

A phase II dose­ranging trial of the early bactericidal activity of PA­824

AH Diacon, R Dawson, J du Bois
  • Antimicrob Agents Chemother
  • 2012

Randomized pilot trial of 8 weeks of bedaquiline (TMC207) for MDR­TB: long­term outcome, tolerability and effect on emergence of drug resistance

AH Diacon, PR Donald, A Pym
  • Antimicrob Agents Chemother
  • 2012

Totally drug-resistant and extremely drug-resistant tuberculosis: the same disease?

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2012