14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

@article{Jrgensen201314StepSO,
  title={14-Step Synthesis of (+)-Ingenol from (+)-3-Carene},
  author={Lars J{\o}rgensen and Steven J McKerrall and Christian A Kuttruff and Felix Ungeheuer and Jakob Felding and Phil S. Baran},
  journal={Science},
  year={2013},
  volume={341},
  pages={878 - 882}
}
Ingenol Ingenuity The diterpenoid i ngenol is the core structure of a topical drug recently commercialized to treat actinic keratosis, a precancerous skin condition. Sourcing the compound from the Euphorbia plants that produce it is relatively inefficient, so Jørgensen et al. (p. 878, published online 1 August) devised a chemical synthesis starting from the comparatively simple and inexpensive monoterpene chiral (+)-3-carene. The synthetic sequence involves 14 steps—less than half as long as… 
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