Corpus ID: 89990089

14-Esters and 13-hydrazones of anthracycline antibiotics of the daunorubicin series: Synthesis and cytostatic activity toward tumor cells sensitive or resistant to doxorubicin

@article{Povarov199514EstersA1,
  title={14-Esters and 13-hydrazones of anthracycline antibiotics of the daunorubicin series: Synthesis and cytostatic activity toward tumor cells sensitive or resistant to doxorubicin},
  author={L. S. Povarov and Leont apos and O. V. eva and Ralph J. Bernacki and O apos and E N Eva and E. I. Salimova and Paula J. Pera and Maria N. Preobrazhenskaya},
  journal={Bioorganicheskaya Khimiya},
  year={1995},
  volume={21},
  pages={925-932}
}
1 Citations
Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants.
TLDR
The new hydrophilic derivatives of 14-hydroxycarminomycin were obtained using 13-dimethyl ketal of14-bromocarminomcin (6) as the starting compound and were less toxic than carminomecin or 14-Hydroxycarmineomycin for leukemia (K562) and breast carcinoma (MCF-7) cells. Expand