14-3-3sigma, the double-edged sword of human cancers.

  title={14-3-3sigma, the double-edged sword of human cancers.},
  author={Zhaomin Li and Jing-Yuan Liu and Jian-Ting Zhang},
  journal={American journal of translational research},
  volume={1 4},
14-3-3sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3sigma has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3… CONTINUE READING