14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta.

@article{Bialkowska20031433ZM,
  title={14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta.},
  author={Katarzyna Bialkowska and Yona Zaffran and Sylvie C Meyer and Joan E. B. Fox},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={33342-50}
}
Integrin-induced cytoskeletal reorganizations are initiated by Cdc42 and Rac1 but little is known about mechanisms by which integrins activate these Rho GTPases. 14-3-3 proteins are adaptors implicated in binding and regulating the function and subcellular location of numerous signaling molecules. In platelets, the 14-3-3 zeta isoform interacts with the… CONTINUE READING