14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

  title={14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport},
  author={Anne Brunet and Fumihiko Kanai and Justine Stehn and Jian Xu and Dilara Sarbassova and John V. Frangioni and Sorab Nariman Dalal and James A. Decaprio and Michael Eldon Greenberg and Michael B. Yaffe},
  journal={The Journal of Cell Biology},
  pages={817 - 828}
14-3-3 proteins regulate the cell cycle and prevent apoptosis by controlling the nuclear and cytoplasmic distribution of signaling molecules with which they interact. Although the majority of 14-3-3 molecules are present in the cytoplasm, we show here that in the absence of bound ligands 14-3-3 homes to the nucleus. We demonstrate that phosphorylation of one important 14-3-3 binding molecule, the transcription factor FKHRL1, at the 14-3-3 binding site occurs within the nucleus immediately… 

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