14-3-3 proteins mediate an essential anti-apoptotic signal.

  title={14-3-3 proteins mediate an essential anti-apoptotic signal.},
  author={Shane C. Masters and Haian Fu},
  journal={The Journal of biological chemistry},
  volume={276 48},
The 14-3-3 proteins are a family of highly conserved eukaryotic regulatory molecules that play important roles in many biological processes including cell cycle control and regulation of cell death. They are able to carry out these effects through binding and modulating the activity of a host of signaling proteins. The ability of 14-3-3 to inhibit Bad and other proapoptotic proteins argues that 14-3-3 can support cell survival. To examine this issue in a global sense, a specific inhibitor of 14… CONTINUE READING

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