14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis

@article{Kawamoto20041433PI,
  title={14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis},
  author={Yasuhiro Kawamoto and Ichiro Akiguchi and Shinichi Nakamura and H Budka},
  journal={Acta Neuropathologica},
  year={2004},
  volume={108},
  pages={531-537}
}
Abstract14-3-3 proteins are highly conserved eukaryotic proteins that regulate various types of signal transduction pathways through phosphorylation-dependent protein-protein interactions. 14-3-3 mRNAs have been shown to be up-regulated in the injured rat motor neurons and in the spinal cords of patients with amyotrophic lateral sclerosis (ALS). To investigate the role of 14-3-3 proteins in ALS, we performed immunohistochemical studies on 14-3-3 using autopsied spinal cords from patients with… CONTINUE READING

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