14-3-3 proteins are required for the inhibition of Ras by exoenzyme S.

@article{Henriksson20001433PA,
  title={14-3-3 proteins are required for the inhibition of Ras by exoenzyme S.},
  author={Maria L. Henriksson and Ulrika Troll{\'e}r and Bengt Hallberg},
  journal={The Biochemical journal},
  year={2000},
  volume={349 Pt 3},
  pages={697-701}
}
14-3-3 proteins play a regulatory role and participate in both signal transduction and checkpoint control pathways. 14-3-3 proteins bind phosphoserine ligands, such as Raf-1 kinase and Bad, by recognizing the phosphorylated consensus motif, Arg-Ser-Xaa-pSer-Xaa-Pro (where 'Xaa' represents 'any residue', and 'pSer' is 'phosphoserine'). However, 14-3-3 proteins must bind unphosphorylated ligands, such as glycoprotein Ibalpha and Pseudomonas aeruginosa exoenzyme S (ExoS), since it has been… CONTINUE READING

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