14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts.

@article{Kumagai19981433PA,
  title={14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts.},
  author={Akiko Kumagai and Peter S. Yakowec and William G. Dunphy},
  journal={Molecular biology of the cell},
  year={1998},
  volume={9 2},
  pages={345-54}
}
Cdc25, the dual-specificity phosphatase that dephosphorylates the Cdc2-cyclin B complex at mitosis, is highly regulated during the cell cycle. In Xenopus egg extracts, Cdc25 is associated with two isoforms of the 14-3-3 protein. Cdc25 is complexed primarily with 14-3-3epsilon and to a lesser extent with 14-3-3zeta. The association of these 14-3-3 proteins with Cdc25 varies dramatically during the cell cycle: binding is high during interphase but virtually absent at mitosis. Interaction with 14… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Similar Papers

Loading similar papers…