• DOI:10.1073/PNAS.92.25.11539
Corpus ID: 37283643

14-3-3 proteins: potential roles in vesicular transport and Ras signaling in Saccharomyces cerevisiae.

@article{Gelperin19951433PP,
  title={14-3-3 proteins: potential roles in vesicular transport and Ras signaling in Saccharomyces cerevisiae.},
  author={D. Gelperin and J. Weigle and K. Nelson and P. Roseboom and K. Irie and K. Matsumoto and S. Lemmon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 25},
  pages={
          11539-43
        }
}

D. Gelperin, J. Weigle, +4 authors S. Lemmon

Published 1995

Biology, Medicine

Proceedings of the National Academy of Sciences of the United States of America

Deletion of the clathrin heavy-chain gene, CHC1, in the budding yeast Saccharomyces cerevisiae results in growth, morphological, and membrane trafficking defects, and in some strains chc1-delta is lethal. A previous study identified five genes which, in multicopy, rescue inviable strains of Chc- yeast. Now we report that one of the suppressor loci, BMH2/SCD3, encodes a protein of the 14-3-3 family. The 14-3-3 proteins are abundant acidic proteins of approximately 30 kDa with numerous isoforms… CONTINUE READING

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