14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.

  title={14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.},
  author={Zhe Xu and Kourtney Graham and Molly J. Foote and Fengshan Liang and Raed Rizkallah and Myra H Hurt and Yanchang Wang and Yuying Wu and Yi Zhou},
  journal={Journal of cell science},
  volume={126 Pt 18},
The aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. Although loading misfolded proteins cargos to dynein motors has been recognized as an important step in the aggresome formation process, the molecular machinery that mediates the association of cargos with the dynein motor is poorly understood. Here, we report a new aggresome-targeting pathway that involves isoforms of 14-3-3, a family of conserved regulatory proteins. 14-3-3 interacts with… CONTINUE READING
16 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…