14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis.

@article{MartnezYlamos20011433PI,
  title={14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis.},
  author={Antonio Mart{\'i}nez-Y{\'e}lamos and Albert Saiz and Raquel S{\'a}nchez-Valle and V Casado and Jos{\'e} Manuel Ram{\'o}n and Francesc Graus and Txomin Arbizu},
  journal={Neurology},
  year={2001},
  volume={57 4},
  pages={722-4}
}
Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) > or =2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8… CONTINUE READING

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