14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax.

Abstract

The Bcl-2 family of proteins comprises well characterized regulators of apoptosis, consisting of anti-apoptotic members and pro-apoptotic members. Pro-apoptotic members possessing BH1, BH2, and BH3 domains (such as Bax and Bak) act as a gateway for a variety of apoptotic signals. Bax is normally localized to the cytoplasm in an inactive form. In response to… (More)
DOI: 10.1074/jbc.A114.207880

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