14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.

@article{Andersen20121433CR,
  title={14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.},
  author={Sofie Dabros Andersen and Guido Keijzers and Emmanouil Rampakakis and Kim Engels and Patricia Luhn and Mahmoud Y M El-Shemerly and Finn Cilius Nielsen and Yuhong Du and Alfred J. May and Vilhelm A. Bohr and Stefano Ferrari and Maria Zannis-Hadjopoulos and Haian Fu and Lene Juel Rasmussen},
  journal={DNA repair},
  year={2012},
  volume={11 3},
  pages={267-77}
}
Human exonuclease 1 (hEXO1) acts directly in diverse DNA processing events, including replication, mismatch repair (MMR), and double strand break repair (DSBR), and it was also recently described to function as damage sensor and apoptosis inducer following DNA damage. In contrast, 14-3-3 proteins are regulatory phosphorserine/threonine binding proteins involved in the control of diverse cellular events, including cell cycle checkpoint and apoptosis signaling. hEXO1 is regulated by post… CONTINUE READING