14-3-3-Regulated Ca2+-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis

@article{Lachaud20131433RegulatedCP,
  title={14-3-3-Regulated Ca2+-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis},
  author={Christophe Lachaud and Elise Prigent and Patrice Thuleau and Sabine Grat and Diane Da Silva and Christian Bri{\`e}re and Christian Mazars and Val{\'e}rie Cotelle},
  journal={Cell Death and Differentiation},
  year={2013},
  volume={20},
  pages={209-217}
}
In eukaryotic cells, sphingoid long chain bases (LCBs) such as sphingosine or phytosphingosine (PHS) behave as second messengers involved in various processes including programmed cell death (PCD). In plants, induction of PCD by LCBs has now been described, but the signalling pathway is still enigmatic. Using Arabidopsis, we identify new key steps in this pathway. We demonstrate that PHS induces activation of the calcium-dependent kinase CPK3, which phosphorylates its binding partners, the 14-3… CONTINUE READING