14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin.

@article{Klein20021433PA,
  title={14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin.},
  author={David C. Klein and Surajit Ganguly and Steven L. Coon and Joan L. Weller and Tom{\'a}{\vs} Ob{\vs}il and Andrew Hickman and Fred Dyda},
  journal={Biochemical Society transactions},
  year={2002},
  volume={30 4},
  pages={365-73}
}
This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkylamine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against proteolysis. This enhances melatonin production >10-fold. Light exposure results in dephosphorylation… CONTINUE READING

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