14-3-3 Binding to Ataxin-1(ATXN1) Regulates Its Dephosphorylation at Ser-776 and Transport to the Nucleus*

@inproceedings{Lai20111433BT,
  title={14-3-3 Binding to Ataxin-1(ATXN1) Regulates Its Dephosphorylation at Ser-776 and Transport to the Nucleus*},
  author={Shaojuan Lai and Brennon L. O'Callaghan and Huda Y Zoghbi and Harry T. Orr},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
Spinocerebellar ataxia type 1 (SCA1) is a lethal neurodegenerative disorder caused by expansion of a polyglutamine tract in ATXN1. A prominent site of pathology in SCA1 is cerebellar Purkinje neurons where mutant ATXN1 must enter the nucleus to cause disease. In SCA1, phosphorylation of ATXN1 at Ser-776 modulates disease. Interestingly, Ser-776 is located within a region of ATXN1 that harbors several functional motifs including binding sites for 14-3-3, and splicing factors RBM17 and U2AF65… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

SCA1—Phosphorylation, a regulator of Ataxin-1 function and pathogenesis

VIEW 9 EXCERPTS
CITES BACKGROUND

Roles of Post-translational Modifications in Spinocerebellar Ataxias

VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.

14-3-3 and Regulation of Ataxin-1 Function 34616 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • S. Strack, J. A. Zaucha, F. F. Ebner, R. J. Colbran, B. E. Wadzinski
  • J. Comp. Neurol. 392,
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL