14-3-3 (Bmh) proteins inhibit transcription activation by Adr1 through direct binding to its regulatory domain.

@article{Parua20101433P,
  title={14-3-3 (Bmh) proteins inhibit transcription activation by Adr1 through direct binding to its regulatory domain.},
  author={Pabitra Kumar Parua and Sooraj Ratnakumar and Katherine A. Braun and Kenneth M. Dombek and Erin M. Arms and Paul M Ryan and Elton T. Young},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 22},
  pages={5273-83}
}
14-3-3 proteins, known as Bmh in yeast, are ubiquitous, highly conserved proteins that function as adaptors in signal transduction pathways by binding to phosphorylated proteins to activate, inactivate, or sequester their substrates. Bmh proteins have an important role in glucose repression by binding to Reg1, the regulatory subunit of Glc7, a protein phosphatase that inactivates the AMP-activated protein kinase Snf1. We describe here another role for Bmh in glucose repression. We show that Bmh… CONTINUE READING
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