14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.

@article{Marzinke20131433AN,
  title={14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.},
  author={Mark A Marzinke and Terri Lynn Mavencamp and Joseph Duratinsky and Margaret Clagett-Dame},
  journal={Archives of biochemistry and biophysics},
  year={2013},
  volume={540 1-2},
  pages={94-100}
}
Neuron navigator 2 (NAV2) is required for all-trans retinoic acid (atRA) to induce neurite outgrowth in human neuroblastoma cells. Further, ectopic overexpression of full-length human NAV2 rescues an axonal elongation defect in the Caenorhabditis elegans unc-53 (NAV2 ortholog) mutant. Using a region of NAV2 that independently associates with the cytoskeleton as bait in a yeast-two-hybrid screen, 14-3-3ε was identified as a novel NAV2 interacting partner. Amino acids 761-960 of NAV2 are… CONTINUE READING
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