14-3-3β regulates the proliferation of glioma cells through the GSK3β/β-catenin signaling pathway.

@article{Gong20131433RT,
  title={14-3-3$\beta$ regulates the proliferation of glioma cells through the GSK3$\beta$/$\beta$-catenin signaling pathway.},
  author={Fanghe Gong and Guo-liang Wang and Jingwen Ye and Tian-dong Li and Hongmin Bai and Weimin Wang},
  journal={Oncology reports},
  year={2013},
  volume={30 6},
  pages={
          2976-82
        }
}
We previously demonstrated that 14-3-3β is overexpressed in astrocytomas; however, the underlying mechanisms are poorly understood. Based on the reported multiple functions of 14-3-3β, we hypothesized that it interacts with glycogen synthase kinase 3 β (GSK3β), which regulates β-catenin-mediated oncogene expression and contributes to tumorigenesis and astrocytoma progression. To test these hypotheses, we used 14-3-3β overexpression vectors and small interfering RNA (siRNA) transfection in the… 
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