131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission.

@article{Pagel2006131IantiCD45AP,
  title={131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission.},
  author={John M Pagel and Frederick R Appelbaum and J. F. Eary and Joseph Rajendran and Darrell R Fisher and Ted Gooley and Katherine L Ruffner and Eneida R Nemecek and Eileen J Sickle and Larry D Durack and Jeanette Carreras and Mary M. Horowitz and Oliver W Press and Ajay K Gopal and Paul J Martin and Irwin D Bernstein and Dana C. Matthews},
  journal={Blood},
  year={2006},
  volume={107 5},
  pages={2184-91}
}
In an attempt to improve outcomes for patients with acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (HCT), we conducted a phase 1/2 study in which targeted irradiation delivered by 131I-anti-CD45 antibody was combined with targeted busulfan (BU; area-under-curve, 600-900 ng/mL) and cyclophosphamide (CY; 120 mg/kg). Fifty-two (88%) of 59 patients receiving a trace 131I-labeled dose of 0.5 mg/kg anti-CD45 murine antibody had higher estimated absorbed radiation in… CONTINUE READING

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