130-kDa smooth muscle myosin light chain kinase is transcribed from a CArG-dependent, internal promoter within the mouse mylk gene.

@article{Yin2006130kDaSM,
  title={130-kDa smooth muscle myosin light chain kinase is transcribed from a CArG-dependent, internal promoter within the mouse mylk gene.},
  author={Feng Yin and A. Hoggatt and Jiliang Zhou and B. Herring},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={290 6},
  pages={
          C1599-609
        }
}
The 130-kDa smooth muscle myosin light chain kinase (smMLCK) is a Ca2+/CaM-regulated enzyme that plays a pivotal role in the initiation of smooth muscle contraction and regulation of cellular migration and division. Despite the critical importance of smMLCK in these processes, little is known about the mechanisms regulating its expression. In this study, we have identified the proximal promoter of smMLCK within an intron of the mouse mylk gene. The mylk gene encodes at least two isoforms of… Expand
Regulation of 130-kDa Smooth Muscle Myosin Light Chain Kinase Expression by an Intronic CArG Element*
TLDR
Overall, these data show that the CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the130-k da smM LCK isoform is specifically required to regulate smooth muscle contractility and small intestine smooth muscle cell proliferation. Expand
Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues.
TLDR
Some of the recent studies that have described the transcriptional regulation of mylk1 gene products in smooth muscle tissues are highlighted and the implications of these findings for regulation of expression of other smooth muscle-specific genes are discussed. Expand
Autoregulatory Control of Smooth Muscle Myosin Light Chain Kinase Promoter by Notch Signaling*
TLDR
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Tumor Necrosis Factor-induced Long Myosin Light Chain Kinase Transcription Is Regulated by Differentiation-dependent Signaling Events
TLDR
Either AP-1 or NFκB can up-regulate long MLCK transcription, but the mechanisms by which TNF up- Regulates intestinal epithelial long M LCK transcription from exon 1A are differentiation-dependent. Expand
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TLDR
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A Novel Role of Brg1 in the Regulation of SRF/MRTFA-dependent Smooth Muscle-specific Gene Expression*
TLDR
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Regulation of serum response factor activity and smooth muscle cell apoptosis by chromodomain helicase DNA-binding protein 8.
TLDR
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Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.
TLDR
The molecular basis of MRTF function is reviewed with particular focus on the role MRTFs play in regulating cardiovascular patterning, vascular smooth muscle cell and cardiomyocyte differentiation and in the pathogenesis of congenital heart disease and vascular proliferative syndromes. Expand
Myocardin-Related Transcription Factors : Critical Coactivators Regulating
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A transcribed pseudogene of MYLK promotes cell proliferation
TLDR
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