130 Evidence for an Ischemic Preconditioning Effect on Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage.

Abstract

64%): The average age was 57 with a Hunt and Hess grade (HH) 3.3. At discharge 10% had died, 33% had a poor outcome (mRS3-5) and 57% had a good outcome (mRS0-2). Analyzing survivors, drastic long term improvement was noted. At three months, 78% of these patients were a mRS 0-2 which improved to 87% by one year. Clipping group (n1⁄4 22 or 36%): The average age was 49 with a HH grade of 2.6. At discharge 14% had died, 27% had a poor outcome and 59% had a good outcome. Analyzing the survivors, dramatic improvement was seen. At three months, 82% of these patients were a mRS 0-2 which improved to 86% at one year. Eight out of 22 (37%) patients had post-operative 3rd nerve palsies. All but one resolved at longest follow up. Radiographic outcome: After initial coiling, 59% achieved a Raymond 1, 36% Raymond 2, and 2.5% Raymond 3. 11/15 Raymond 2 or 3 patients had long term follow up. In this group, 46% had stable disease that did not require treatment, 27% spontaneously resolved, and 27% required re-treatment. One patient (4.5%) in the Clipping group had a residual stable lesion at one year.

DOI: 10.1227/01.neu.0000417720.26333.46

Cite this paper

@article{Kim2012130EF, title={130 Evidence for an Ischemic Preconditioning Effect on Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage.}, author={Young Woo Kim and Christopher S Ogilvy and Katie L Pricola and John F. Reavey-Cantwell and Craig R Kelman and Gregory Joseph Zipfel and Chad W. Washington and Felipe Albuquerque and Mahrokh Yashar and Sarthak Kalani and Brian Lim Hoh}, journal={Neurosurgery}, year={2012}, volume={71 2}, pages={E553} }