13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy.

@article{Adams200513cisRA,
  title={13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy.},
  author={Judith A. Adams and {\'E}va {\'I}risz Kiss and Ana Bel{\'e}n Arroyo and Mahnaz Bonrouhi and Qingnan Sun and Zhen Li and Norbert Gretz and Anna K. D. Schnitger and C C Zouboulis and Manfred Wiesel and Juergen Wagner and Peter Jon Nelson and Hermann-Josef Gr{\"o}ne},
  journal={The American journal of pathology},
  year={2005},
  volume={167 1},
  pages={285-98}
}
Chronic allograft nephropathy is characterized by chronic inflammation and fibrosis. Because retinoids exhibit anti-proliferative, anti-inflammatory, and anti-fibrotic functions, the effects of low and high doses of 13-cis-retinoic acid (13cRA) were studied in a chronic Fisher344-->Lewis transplantation model. In 13cRA animals, independent of dose (2 or 20 mg/kg body weight/day) and start (0 or 14 days after transplantation) of 13cRA administration, serum creatinine was significantly lower and… CONTINUE READING

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