13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells.

@article{Altmann200713OxoODEIA,
  title={13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells.},
  author={Reinhold Altmann and Martin Hausmann and Tanja Spoettl and Michael Gruber and Arthur W. Bull and Katrin Menzel and Daniela Vogl and Hans Herfarth and Juergen Schoelmerich and Werner Falk and Gerhard Rogler},
  journal={Biochemical pharmacology},
  year={2007},
  volume={74 4},
  pages={612-22}
}
BACKGROUND The ligand activated nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) induces transcriptional repression of pro-inflammatory factors. Activation of PPARgamma is followed by amelioration of colitis in animal models of inflammatory bowel disease (IBD). A reduced expression of PPARgamma was found in epithelial cells of patients with ulcerative colitis. The eicosanoids 13-HODE and 15-HETE are products of 12/15-lipoxygenase (LOX) and endogenous ligands… CONTINUE READING

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