13-Cis-retinoic acid decreases hypothalamic cell number in vitro
@article{Griffin201013CisretinoicAD, title={13-Cis-retinoic acid decreases hypothalamic cell number in vitro}, author={Jennifer N. Griffin and Daniel Pinali and Kaylan Olds and Na Lu and Lindsay Appleby and Louis Doan and Michelle A. Lane}, journal={Neuroscience Research}, year={2010}, volume={68}, pages={185-190} }
13 Citations
Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive‐like behavior
- Biology, PsychologyHippocampus
- 2016
It is suggested that RA‐induced impairments in hippocampal neurogenesis correlate with depression‐like symptoms but not with spatial learning and memory in this design, and manipulations aimed to enhance neuroGenesis may help ameliorate emotional aspects of RA‐associated mood disorders.
Isotretinoin and FoxO 1 A scientific hypothesis
- Biology, Medicine
- 2011
Substantial indirect evidence is provided for isotretinoin’s mode of action by upregulation of forkhead box class O (FoxO) transcription factors by means of translational research.
Isotretinoin and FoxO1: A scientific hypothesis.
- Biology, MedicineDermato-endocrinology
- 2011
Substantial indirect evidence is provided for isotretinoin's mode of action by upregulation of forkhead box class O (FoxO) transcription factors and explains most therapeutic, adverse and teratogenic effects of isot retinoin in the treatment of acne by a common mode of FoxO-mediated transcriptional regulation.
Isotretinoin and FoxO1
- Biology, Medicine
- 2011
Substantial indirect evidence is provided for isotretinoin´s mode of action by upregulation of forkhead box class O (FoxO) transcription factors and explains most therapeutic, adverse and teratogenic effects of isot retinoin in the treatment of acne by a common mode of FoxO-mediated transcriptional regulation.
Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity.
- Medicine, BiologyActa dermato-venereologica
- 2017
It is proposed that apoptosis may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (teratogenicity), hippocampal neurones (depression), epidermal keratinocytes and mucosa cells (mucocutaneous side-effects), and hepatocytes (release of transaminases and very low-density lipoproteins).
Low dosages of vitamin A may cause a decrease in the total neuron number of fetal hippocampal rat cells.
- Medicine, BiologyBratislavske lekarske listy
- 2020
It is demonstrated that vitamin A, beginning from the dosage of 20000 IU/kg, is decreasing the total hippocampal neuron numbers during the critical period of embryonic brain development and that apoptosis may not be the only factor in this outcome.
Adverse effects of maternal retinyl palmitate, a vitamin A compound, on the fetal liver.
- MedicineInternational journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
- 2022
This study shows that vitamin A administered during gestation days 10-12 has a suppressive effect on the developing rat liver when the dose exceeds 10,000 IU/kg, probably due to increased apoptosis and suppressed cell division.
Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed
- Medicine, PsychologyJournal of affective disorders reports
- 2021
Does folinic acid ameliorates retinoic acid induced teratogenicity in chick embryo?
- BiologyJPMA. The Journal of the Pakistan Medical Association
- 2016
Irrespective of the presence of folinic acid, prenatal retinoic acid exposure significantly altered the hatchability characteristics in the experimental groups compared to the control.
61 References
13-cis-Retinoic Acid Alters Intracellular Serotonin, Increases 5-HT1A Receptor, and Serotonin Reuptake Transporter Levels In Vitro
- BiologyExperimental biology and medicine
- 2007
Whether 13-cis-RA regulates components involved in serotonergic neurotransmission in vitro is examined, and increases in both 5-HT1A receptor and SERT proteins may lead to decreased serotonin availability at synapses.
Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice.
- Biology, PsychologyEuropean journal of pharmacology
- 2009
Chronic Administration of 13-Cis-Retinoic Acid Increases Depression-Related Behavior in Mice
- Biology, PsychologyNeuropsychopharmacology
- 2006
Results suggest that administration of 13-cis-RA increases depression-related behaviors in mice, and is comparable to those reported in human patients taking Accutane.
13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes.
- Biology, MedicineThe Journal of investigative dermatology
- 2006
It is indicated that 13-cis RA causes cell cycle arrest and induces apoptosis in SEB-1 sebocytes by a RAR-independent mechanism, which contributes to its sebosuppressive effect and the resolution of acne.
13‐cis‐retinoic acid alters the cellular morphology of slice‐cultured serotonergic neurons in the rat
- BiologyThe European journal of neuroscience
- 2008
The results suggest that 13‐cis‐RA exerts its action on slice‐cultured 5‐HT neurons, at least in part, through specific retinoid receptors, and RXR has a greater influence on the morphology of 5‐ HT neurons than RAR.
13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2004
It is demonstrated that a clinical dose of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task.
In vitro treatment with retinoids decreases bcl‐2 protein expression and enhances dexamethasone‐induced cytotoxicity and apoptosis in multiple myeloma cells
- Biology, ChemistryEuropean journal of haematology
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The combined inhibitory activity of retinoids and DEX could be attributed to an increased induction of apoptosis, and this effect may be mediated by a reduced intracellular expression of BCL‐2 protein, which indeed observed after prolonged in vitro treatment with retinoid.
Chronic treatment with 13-cis-retinoic acid changes aggressive behaviours in the resident–intruder paradigm in rats
- Biology, PsychologyEuropean Neuropsychopharmacology
- 2009
Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons
- BiologyJournal of neurochemistry
- 2008
RAs at high concentrations cause a negative effect on the dendritic morphology of cultured hippocampal neurons through RA receptors, while RAs at low concentrations exert a positive influence on cultured hippocampusal neurons.
Activation of Retinoic Acid Receptor-dependent Transcription by All-trans-retinoic Acid Metabolites and Isomers*
- Biology, ChemistryThe Journal of Biological Chemistry
- 2002
ATRA metabolites can bind to and activate the three RARs with variable relative affinity but with similar efficacy, suggesting that ATRA metabolites may activate several signaling pathways and probably play an important role in cellular physiology and cancer therapy.