13-Cis-retinoic acid decreases hypothalamic cell number in vitro

@article{Griffin201013CisretinoicAD,
  title={13-Cis-retinoic acid decreases hypothalamic cell number in vitro},
  author={Jennifer N. Griffin and Daniel Pinali and Kaylan Olds and Na Lu and Lindsay Appleby and Louis Doan and Michelle A. Lane},
  journal={Neuroscience Research},
  year={2010},
  volume={68},
  pages={185-190}
}
13-Cis-retinoic acid (13-cis-RA) causes depression-related behavior in mice. Hypothalamic dysregulation has been implicated in clinical depression. In fact, apoptosis of hypothalamic neurons may lead to depression after myocardial infarction. Our objective was to determine if 13-cis-RA affects cultured hypothalamic cell number. Treatment of GT1-7 hypothalamic cells with 10μM 13-cis-RA for 48h decreased cell growth to 45.6±13% of control. To determine if this decrease in cell number was due to… Expand
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