13-CIS RETINOIC ACID AND ACNE

@article{Jones198013CISRA,
  title={13-CIS RETINOIC ACID AND ACNE},
  author={H Jones and D. Blanc and William James Cunliffe},
  journal={The Lancet},
  year={1980},
  volume={316},
  pages={1048-1049}
}
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121 Citations
Highly Influential Citations
1
Background Citations
19
Results Citations
3

121 Citations

A dose‐response study of 13‐cis‐retinoic acid in acne vulgaris

13‐cis‐retinoic acid has been used as a single agent in the treatment of seventy‐six patients with previously unresponsive cystonodular acne and ninety per cent of the patients responded with a 70% improvement in the acne severity.

The effect of 13-cis-retinoic acid on sebaceous glands.

The effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy support the concept that linoleate may be of importance in the pathogenesis of acne.

13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers

It is suggested from the present data that a high initial dosage of 13-cis-retinoic acid be chosen in order to obtain optimal long-term therapeutic effects in patients of the German multicenter study with severe conglobate acne.

Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion.

Relapse Rate of Acne Conglobata after Stopping Isotretinoin

13-cis-retinoic acid has been shown to possess excellent efficacy in acne conglobata, acne and in severe papular pustular rosacea as well as in Gram-negative folliculitis.

A comparison of dapsone with 13‐cis retinoic acid in the treatment of nodular cystic acne

It is concluded that dapsone is clearly inferior to 13‐cis retinoic acid in the treatment of nodular cystic acne.

New therapy for severe cystic acne.

Although isotretinoin is expensive, a course of treatment usually clears the troublesome lesions and a prolonged remission often follows, and side effects and alterations in patients' laboratory test results do occur; these appear to be lessened by reduction in dosage and to be fully reversible when the drug is discontinued.

13-cis-Retinoic Acid in Acne — Mechanism of Action

This chapter will consider the effect of 13-cis-retinoic acid on these four factors: sebum production, ductal hyperkeratinization, cutaneous and ductal bacteria and inflammation.

Use of Isotretinoin in Severe Cases with Papular Pustular Acne

The excellent efficacy of 13-cis-retinoic acid in cases with conglobate and cystic acne, as well as in Gram-negative folliculitis, is well documented.

FACIAL PYOGENIC GRANULOMA‐LIKE LESIONS UNDER ISOTRETINOIN THERAPY

  • JOSEPH HAGLERE. HodakM. DavidMIRIAM SANDBANK
  • Medicine
    International journal of dermatology
  • 1992
A male patient with severe cystic acne was treated with 13‐cis‐retinoic acid in a dosage of 1 mg/kg/day and multiple pyogenic‐like lesions on his face appeared during the second week of treatment.
...

References

SHOWING 1-9 OF 9 REFERENCES

Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.

Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy; the mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.

Sebaceous gland inhibition from combined glucocorticoid-estrogen treatment.

Sebum production in seven hirsute women was found to be markedly inhibited by low-dosage glucocorticoid therapy, usually 5 to 10 mg of prednisone daily, combined with the cyclic administration of ethinyl estradiol in the form of oral contraceptive medication.

The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition.

Changes in sebum production and skin surface lipid composition during the oral treatment with 13cis-retinoic acid were consonant with changes in the relative contributions of sebum and epidermal lipid to the surface film, except that at very low levels of Sebum production there might be preferential preservation of squalene synthesis.

Stimulation of immune response in lung cancer patients by vitamin A therapy.

The immune potentiating effects of vitamin A therapy, as well as the demonstrated direct effect on the tumor, introduces a wide range of combination therapies.

Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject

The quantitative changes in body hair growth, and sebaceous secretion, as well as plasma sex hormone binding globulin, luteinizing hormone and follicle stimulating hormone, testosterone and…

THE PREVALENCE OF ACNE VULGARIS IN ADOLESCENCE

SUMMARY.— We examined 1555 school children aged 8 to 18 and graded them according to the presence and severity of acne lesions on the face and neck. Comedones were present in a large proportion of…

The Quantitative Gravimetric Determination of Sebum Production

The present report is concerned with a simplified quantitative tech-nic for measuring sebum production adapted from the technics of Miescher and Schonberg, and Kligman and Shelley, and the principle is simply to absorb the sebum on paper as soon as it reaches the surface, thus trapping thesebum before it can flow away.

THE RATE OF SEBUM EXCRETION IN MAN

Modification of the method with careful attention to detail has increased the reproducibility of the results and there is good agreement of the Results on both sides of the forehead and in collections made over a 7‐week period.

From vitamin A to retinoids. Modern trends in the field of oncology and dermatology.