13-CIS RETINOIC ACID AND ACNE

@article{Jones198013CISRA,
  title={13-CIS RETINOIC ACID AND ACNE},
  author={H. Jones and D. Blanc and W. Cunliffe},
  journal={The Lancet},
  year={1980},
  volume={316},
  pages={1048-1049}
}
Patients with very severe acne which had not responded to conventional treatment were given 13-cis retinoic acid (0.1 mg-1.0 mg/kg body-weight) in a double-blind dose response study. Sebum excretion rate was reduced by 75% at 4 weeks, and all patients had an 80% improvement in their acne severity after 4 months treatment. There were dose-related side-effects, particularly dryness of the skin and mucous membranes. No patient wished to stop treatment. 
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