13-CIS RETINOIC ACID AND ACNE

@article{Jones198013CISRA,
  title={13-CIS RETINOIC ACID AND ACNE},
  author={H Jones and D. Blanc and William James Cunliffe},
  journal={The Lancet},
  year={1980},
  volume={316},
  pages={1048-1049}
}
A dose‐response study of 13‐cis‐retinoic acid in acne vulgaris
TLDR
13‐cis‐retinoic acid has been used as a single agent in the treatment of seventy‐six patients with previously unresponsive cystonodular acne and ninety per cent of the patients responded with a 70% improvement in the acne severity.
The effect of 13-cis-retinoic acid on sebaceous glands.
TLDR
The effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy support the concept that linoleate may be of importance in the pathogenesis of acne.
13-cis-retinoic acid in conglobate acne. A follow-up study of 14 trial centers
TLDR
It is suggested from the present data that a high initial dosage of 13-cis-retinoic acid be chosen in order to obtain optimal long-term therapeutic effects in patients of the German multicenter study with severe conglobate acne.
Effect of oral 13‐cis‐retinoic acid on serum lipids
TLDR
Serum lipid concentrations were measured in patients with severe acne before, during and after treatment with 0.8 mg/kg 13‐cis‐retinoic acid for 3 months and suggest that use of the drug in acne is likely to be limited by its toxicity.
Relapse Rate of Acne Conglobata after Stopping Isotretinoin
TLDR
13-cis-retinoic acid has been shown to possess excellent efficacy in acne conglobata, acne and in severe papular pustular rosacea as well as in Gram-negative folliculitis.
A comparison of dapsone with 13‐cis retinoic acid in the treatment of nodular cystic acne
TLDR
It is concluded that dapsone is clearly inferior to 13‐cis retinoic acid in the treatment of nodular cystic acne.
New therapy for severe cystic acne.
TLDR
Although isotretinoin is expensive, a course of treatment usually clears the troublesome lesions and a prolonged remission often follows, and side effects and alterations in patients' laboratory test results do occur; these appear to be lessened by reduction in dosage and to be fully reversible when the drug is discontinued.
13-cis-Retinoic Acid in Acne — Mechanism of Action
TLDR
This chapter will consider the effect of 13-cis-retinoic acid on these four factors: sebum production, ductal hyperkeratinization, cutaneous and ductal bacteria and inflammation.
Use of Isotretinoin in Severe Cases with Papular Pustular Acne
TLDR
The excellent efficacy of 13-cis-retinoic acid in cases with conglobate and cystic acne, as well as in Gram-negative folliculitis, is well documented.
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References

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Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.
TLDR
Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy; the mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.
Sebaceous gland inhibition from combined glucocorticoid-estrogen treatment.
• Sebum production in seven hirsute women was found to be markedly inhibited by low-dosage glucocorticoid therapy, usually 5 to 10 mg of prednisone daily, combined with the cyclic administration of
The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition.
TLDR
Changes in sebum production and skin surface lipid composition during the oral treatment with 13cis-retinoic acid were consonant with changes in the relative contributions of sebum and epidermal lipid to the surface film, except that at very low levels of Sebum production there might be preferential preservation of squalene synthesis.
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TLDR
The immune potentiating effects of vitamin A therapy, as well as the demonstrated direct effect on the tumor, introduces a wide range of combination therapies.
Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject
The quantitative changes in body hair growth, and sebaceous secretion, as well as plasma sex hormone binding globulin, luteinizing hormone and follicle stimulating hormone, testosterone and
THE PREVALENCE OF ACNE VULGARIS IN ADOLESCENCE
SUMMARY.— We examined 1555 school children aged 8 to 18 and graded them according to the presence and severity of acne lesions on the face and neck. Comedones were present in a large proportion of
The Quantitative Gravimetric Determination of Sebum Production
TLDR
The present report is concerned with a simplified quantitative tech-nic for measuring sebum production adapted from the technics of Miescher and Schonberg, and Kligman and Shelley, and the principle is simply to absorb the sebum on paper as soon as it reaches the surface, thus trapping thesebum before it can flow away.
THE RATE OF SEBUM EXCRETION IN MAN
TLDR
Modification of the method with careful attention to detail has increased the reproducibility of the results and there is good agreement of the Results on both sides of the forehead and in collections made over a 7‐week period.