129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

@article{Manson1994129OlaMC,
  title={129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal},
  author={Jean C Manson and Alan R. Clarke and Martin Hooper and L. Aitchison and Irene McConnell and James Hope},
  journal={Molecular Neurobiology},
  year={1994},
  volume={8},
  pages={121-127}
}
The neural membrane glycoprotein PrP is implicated in the pathogenesis of the transmissible spongiform encephalopathies; however, the normal function of PrP and its precise role in disease are not understood. Recently, gene targeting has been used to produce mice withneo/PrP fusion transcripts, but no detectable PrP protein in the brain (1). Here we report the use of a different targeting strategy, to produce inbred mice with a complete absence of both PrP protein and mRNA sequences. At 7 mo of… CONTINUE READING
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129/01a PrP Null Mice

  • M. Bruce, P A.McBride, C EFarquhar
  • Molecular Neurobiology Volume
  • 1989
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