125I-endothelin-1 and 125I-big endothelin-1 in rat tissues: autoradiographic localization and receptor binding

@article{Neuser1991125Iendothelin1A1,
  title={125I-endothelin-1 and 125I-big endothelin-1 in rat tissues: autoradiographic localization and receptor binding},
  author={D. Neuser and Wolfram Steinke and H G Dellweg and Stanislav Kazda and J. -P. Stasch},
  journal={Histochemistry},
  year={1991},
  volume={95},
  pages={621-628}
}
The potent vasoconstrictor peptide, endothelin-1 (ET-1), which exhibits a characteristically long-acting activity in vitro and in vivo, is thought to be generated in endothelial cells from a less active intermediate, big endothelin-1 (big ET-1). In addition to ET-1, big ET-1 is also present in the circulation. The autoradiographic localization of 125I-big ET-1 and 125I-ET-1 has been studied after intravenous administration in rat tissues. Highest enrichment of radioactivity was found in the… CONTINUE READING