125I-Tyro-sauvagine: a novel high affinity radioligand for the pharmacological and biochemical study of human corticotropin-releasing factor 2 alpha receptors.

@article{Grigoriadis1996125ITyrosauvagineAN,
  title={125I-Tyro-sauvagine: a novel high affinity radioligand for the pharmacological and biochemical study of human corticotropin-releasing factor 2 alpha receptors.},
  author={D. G. E. Grigoriadis and Xue Jun Liu and Jerrylaine Vaughn and Steve C F Palmer and Conal D. True and Wylie W. Vale and Nicholas Ling and Errol B De Souza},
  journal={Molecular pharmacology},
  year={1996},
  volume={50 3},
  pages={679-86}
}
Corticotropin-releasing factor (CRF) receptors encoded by two distinct genes have recently been identified and termed CRF1 and CRF2. CRF and the non-mammalian-related peptide sauvagine bind to and activate CRF1 receptors with high affinity and equal potency. Although CRF is significantly weaker at the CRF2 receptor, sauvagine retains its high affinity… CONTINUE READING