123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment.

@article{Mitsis2009123I5IA85380SI,
  title={123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment.},
  author={Effie M. Mitsis and Kristina M Reech and F. Bois and Gilles Tamagnan and Martha G Macavoy and John P. Seibyl and Julie K. Staley and Christopher H. van Dyck},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2009},
  volume={50 9},
  pages={1455-63}
}
UNLABELLED Postmortem binding studies have established that the concentration of alpha(4)beta(2)-nicotinic acetylcholine receptors (alpha(4)beta(2)-nAChR) is reduced in advanced Alzheimer disease (AD). However, the status of this receptor in mild or prodromal AD has remained the subject of controversy. METHODS We compared alpha(4)beta(2)-nAChR availability in 8 brain regions of living human subjects who had AD and mild cognitive impairment (MCI) with that in age-matched healthy control… CONTINUE READING
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Alpha 4 beta 2 nicotinic receptor status in Alzheimer ’ s disease using 123 I - 5 IA - 85380 SPECT

  • JT O’Brien, SJ Colloby, S Pakrasi
  • J Neurol Neurosurg Psychiatry
  • 2007

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