123I-2-iodo-tyrosine, a new tumour imaging agent: human biodistribution, dosimetry and initial clinical evaluation in glioma patients

@article{Keyaerts2006123I2iodotyrosineAN,
  title={123I-2-iodo-tyrosine, a new tumour imaging agent: human biodistribution, dosimetry and initial clinical evaluation in glioma patients},
  author={Marleen Keyaerts and Tony Lahoutte and Bart Neyns and Vicky Caveliers and Chris Vanhove and Hendrik Everaert and Ken Kersemans and Philippe R. Franken and John Mertens and Axel Bossuyt},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2006},
  volume={34},
  pages={994-1002}
}
123I-2-iodo-tyrosine (123I-2IT) has been identified as a promising new amino acid tracer in animals. Uptake is mediated by LAT1 transport, which is increased in tumour cells. In this study we present the human biodistribution and first clinical results in glioma patients. For the biodistribution study, six male volunteers received 60–95 MBq 123I-2IT. Whole-body scans and blood and urine samples were obtained up to 24 h after injection; dosimetry was calculated using OLINDA 1.0 software. Initial… CONTINUE READING

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